Probiotics: Possible Strategies to Prevent Necrotizing Enterocolitis in Neonates

Probiotics, Prebiotics, and Synbiotics for the Prevention of Necrotizing Enterocolitis.

Necrotizing enterocolitis (NEC) is a devastating intestinal disease in preterm infants characterized by barrier disruption, intestinal microbial dysbiosis, and persistent inflammation of the colon, which results in high mortality rates. Current strategies used to manage this disease are not sufficient, although the use of human breast milk reduces the risk of NEC. Mother's milk is regarded as a...

Prevention of necrotizing enterocolitis with probiotics: a systematic review and meta-analysis

CONTEXT Necrotizing enterocolitis (NEC) is the most frequent gastrointestinal emergency in neonates. The microbiome of the preterm gut may regulate the integrity of the intestinal mucosa. Probiotics may positively contribute to mucosal integrity, potentially reducing the risk of NEC in neonates. OBJECTIVE To perform an updated systematic review and meta-analysis on the efficacy and safety of ...

Probiotics, Prebiotics, and Synbiotics for the Prevention of Necrotizing Enterocolitis12

Necrotizing enterocolitis (NEC) is a devastating intestinal disease in preterm infants characterized by barrier disruption, intestinal microbial dysbiosis, and persistent inflammation of the colon, which results in high mortality rates. Current strategies used to manage this disease are not sufficient, although the use of human breast milk reduces the risk of NEC. Mother’s milk is regarded as a...

Effects of Probiotics on the Reduction in Incidence of Necrotizing Enterocolitis in Premature (< 37 Weeks Gestation) Neonates

Preventing necrotizing enterocolitis by food additives in neonates

BACKGROUND Necrotizing enterocolitis (NEC) is a serious multifactorial gastrointestinal disease which is often discovered in premature infants. Various additives have been used to prevent NEC; yet, their relative efficacy and safety remain disputed. This study aims to compare the efficacy and safety of 5 food additives, namely, probiotics, probiotics + fructo-oligosaccharides, pentoxifylline, a...